A few things to troubleshoot:
Make sure Ledger firmware and the Ledger Live app are up to date.
Check that you have enough funds to complete the transaction.
Enable Blind Signing if you’re trying to sign a transaction.
Disconnect and reconnect your Ledger (avoid USB hubs, try another port if needed).
If you're still having issues, remove and re-add your Ledger wallet to Metamask.
To double check if this issue specific to connecting to Manifold Studio/Products, you can test out signing/verifying with Etherscan here: https://etherscan.io/verifiedsignatures#